Spatial Omics services: 

Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data. Bahl E, Chatterjee S, Mukherjee U, Elsadany M, Vanrobaeys Y, Lin LC, McDonough M, Resch J, Giese KP, Abel T, Michaelson JJ. Nat Commun. 2024 Jan 26;15(1):779. doi: 10.1038/s41467-023-44503-5. PMID: 38278804; PMCID: PMC10817898. 

Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation.  Vanrobaeys Y, Peterson ZJ, Walsh EN, Chatterjee S, Lin LC, Lyons LC, Nickl-Jockschat T, Abel T. Nature Communications, (2023);14(1):7095. doi: 10.1038/s41467-023-42751-z. PMID: 37925446; PMCID: PMC10625558.

Gene Expression within a human choroidal neovascular membrane using spatial transcriptomics.  Voigt A, Mullin N, Navratil E, Flamme-Wiese M, Lin LC, Scheetz T, Han I, Stone E, Tucker B, and Mullins R. (2023) Investigative Ophthalmology & Visual Science. 64:40. doi:10.1167/iovs.64.13.40. PMID: 37878301. PMCID: PMC10615143 

Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.  Vanrobeys Y, Mukherjee U, Langmack L, Bahl E, Lin LC, Michaelson JJ, Abel T, Chatterjee S. Nature Communications, 2023 Sep 29;14(1):6100. doi: 10.1038/s41467-023-41715-7. PMID: 37773230; PMCID: PMC10541893.

Activity-induced gene expression in the human brain.  Snehajyoti Chatterjee, Brian J Park, Yann Vanrobaeys, Shane A Heiney, Ariane E Rhone, Kirill V Nourski, Lucy Langmack, Utsav Mukherjee, Christopher K Kovach, Zsuzsanna Kocsis, Yukiko Kikuchi, Christopher I Petkov, Marco M Hefti, Ethan Bahl, Jacob J Michaelson, Hiroto Kawasaki, Hiroyuki Oya, Matthew A Howard III, Thomas Nickl-Jockschat, Li-Chun Lin, Ted Abel. bioRxiv 2023 Sep 21:2023.09.21.558812. doi: https://doi.org/10.1101/2023.09.21.558812.  PMID: 37790527; PMCID: PMC10542502.

Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation.  Sinem Koc-Gunel, Lalit K. Gautam, Ben A. Calvert, Shubha Murthy, Noa C. Harriott, Janna C. Nawroth, Beiyun Zhou, Vera P. Krymskaya, Amy L. Ryan. bioRxiv [Preprint]. 2024 Sep 6:2023.06.12.544372. doi: 10.1101/2023.06.12.544372. PMID: 37398026; PMCID: PMC10312665.

DNA methylation effects on Van der Woude Syndrome phenotypic variability.  Seaberg A, Awotoye W, Qian F, Dunlay L, Butali A, Murray J, Moreno-Uribe L; Petrin A. Front Dent Med. (2023) ;4:1120948. doi: 10.3389/fdmed.2023.1120948. PMID: 36936396; PMCID: PMC10019782.

Brain and Blood Banking services:

Regulator of G protein signaling 6 mediates exerciseinduced recovery of hippocampal neurogenesis, learning, and memory in a mouse model of Alzheimer's disease.  Spicer MM, Yang J, Fu D, DeVore AN, Lauffer M, S Atasoy N, Atasoy D, A Fisher R.  Neural Regen Res. 2024 Sep 6. doi: 10.4103/NRR.NRR-D-23-01993. Epub ahead of print. PMID: 39248184.

Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer’s disease.  Pierson SR, Fiock KL, Wang R, Balasubramanian N, Reinhardt J, Khan KM, James TD, Hunter ML, Cooper BJ, Williamsen HR, Betters R, Deniz K, Lee G, Aldridge G, Hefti MM, Marcinkiewcz CA.  Mol Psychiatry. 2024 Aug 14. doi: 10.1038/s41380-024-02664-9. PMID: 39143322.

Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial. Voss MW, Oehler C, Daniels W, Sodoma M, Madero B, Kent J, Jain S, Jung M, Nuckols VR, DuBose LE, Davis KG, O'Deen A, Hamilton C, Baller K, Springer J, Rivera-Dompenciel A, Pipoly M, Muellerleile M, Nagarajan N, Bjarnason T, Harb N, Lin LC, Magnotta V, Hazeltine E, Long JD, Pierce GL.  Contemp Clin Trials. 2024 Oct;145:107647. doi: 10.1016/j.cct.2024.107647. PMID: 39095013; PMCID: PMC11438497.

Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens.  Marcinkiewcz C, Wang R, Khan K, Balasubramanian N, James T, Pushpavathi S, Kim D, Pierson S, Wu Q, Niciu M, Hefti M.  Res Sq [Preprint]. 2023 Jul 5:rs.3.rs-2992781. doi: 10.21203/rs.3.rs-2992781/v1. PMID: 37461716; PMCID: PMC10350230.

A Pilot Study of ex vivo Human Prefrontal RNA Transcriptomics in Parkinson’s Disease. Lin LC, Cole RC, Greenlee JDW, Narayanan NS. Cell Mol Neurobiol. 2023 Aug;43(6):3037-3046. doi: 10.1007/s10571-023-01334-8. Epub 2023 Mar 23. PMID: 36952070; PMCID: PMC10566549.

Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies. Fiock KL, Betters RK, Hefti MM.  J Histochem Cytochem. 2023 Feb;71(2):73-86. doi: 10.1369/00221554231158428. Epub 2023 Mar 2. PMID: 36861683; PMCID: PMC10071402.

An 18-month-old with white matter calcifications and seizures. Fiock KL, Lin LC, Colwell S, Hefti MM. Brain Pathol. 2022 Sep;32(5):e13082. doi: 10.1111/bpa.13082. Epub 2022 Jun 14. PMID: 35701888; PMCID: PMC9425002.

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.   Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M.  Cell. 2022 Jul 7;185(14):2452-2468.e16. doi: 10.1016/j.cell.2022.06.008. Epub 2022 Jun 13. PMID: 35768006; PMCID: PMC9189143.

Neuropathology of COVID-19. Lin LC, Hollis B, Hefti MM.  Indian J Pathol Microbiol. 2022 May;65(Supplement):S146-S152. doi: 10.4103/ijpm.ijpm_1103_21. PMID: 35562145.

Microvascular Injury in the Brains of Patients with Covid-19. Lee MH, Perl DP, Nair G, Li W, Maric D, Murray H, Dodd SJ, Koretsky AP, Watts JA, Cheung V, Masliah E, Horkayne-Szakaly I, Jones R, Stram MN, Moncur J, Hefti MM, Folkerth RD, Nath A. N Engl J Med. 2021 Feb 4;384(5):481-483. doi: 10.1056/NEJMc2033369. Epub 2020 Dec 30. PMID: 33378608; PMCID: PMC7787217.

DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan. Langbehn KE, Carlson-Stadler Z, van der Plas E, Hefti MM, Dawson JD, Moser DJ, Nopoulos PC. Neurol Genet.  2020 Dec 21;7(1):e537. doi: 10.1212/NXG.0000000000000537. PMID: 33575482; PMCID: PMC7862092.

Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. Fiock KL, Smalley ME, Crary JF, Pasca AM, Hefti MM. eNeuro. 2020 May 28;7(3):ENEURO.0058-20.2020. doi: 10.1523/ENEURO.0058-20.2020. PMID: 32393582; PMCID: PMC7262004.

Conference Posters:

Sex Differences of APOE in the prefrontal cortex of patients with Major Depressive Disorder. Eggmann S, Lin LC. Spring Undergraduate Research Festival (SURF). 2023.

The Pathophysiology of Attention-Deficit Hyperactivity Disorder, Parkinson's Disease, & Lewy Body Dementia. Jaeger P, Lin LC. Spring Undergraduate Research Festival (SURF). 2023.

Human dorsal raphe tau pathology and related depressive-like behaviors in adult C57BL/6J mice. Pierson S, Fiock K, Khan M, Hefti M, Marcinkiewcz C. Society for Neuroscience Annual Meeting, San Diego, CA. 2022

Optimizing immunofluorescence staining of microglia in thick human brain tissue. Strief D & Dailey M. Fall Undergraduate Research Festivals (FURF). 2022. 

Selective vulnerability in von Economo neurons with frontotemporal lobar degeneration. Jendro M, Hollis B, Lin LC. Fall Undergraduate Research Festivals (FURF). 2022. 

Convergency of Attention-Deficit Hyperactivity Disorrder and Parkinson's Disease. Jaeger P,  Hollis B, Lin LC. Fall Undergraduate Research Festivals (FURF). 2022. 

Molecular Characterization of Neovascular AMD in Human Eyes using Spatial Transcriptomics and Single Cell RNA Sequencing. Mullins RF, Voigt AP, Scheetz TE, Mullin NK, Flamme-Wiese, MJ,  Lin, LC,Stone EM, Han I; Tucker BA. Association for Research in Vision and Ophthalmology (ARVO). 2022.

Spatial transcriptomics reveals unique gene expression changes in different regions after sleep deprivation. Vanrobaeyes Y, Walsh EN, Lyons LC, Lin LC, Abel T, Synapse. 2022.

Neuroestimator: using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data. Chatterjee S, Bahl E, Elsadany M, Vanrobaeys Y, Lin LC, Giese K, Abel T, Michaelson JJ.  Society for Neuroscience Annual Meeting, San Diego, CA. 2021.

Probing the Impact of SARS-CoV-2 (COVID-19) in the Human Brain. Hollis B, Lin LC. Fall Undergraduate Research Festivals (FURF). 2021.