Li-Chun (Queena) Lin, PhD, MS.

NeuroBank Core, Founding Director

Email: li-chun-lin@uiowa.edu

Current positions:

• Founding Director, Iowa NeuroBank Core, Carver College of Medicine, University of Iowa
• Iowa Neuroscience Institute (Primary Appointment)
• Department of Neurology, Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa (Joint Appointment)
• Research Council Committee, University of Iowa

Queena Lin, Ph.D, and her colleagues in the Iowa Neuroscience Institute's NeuroBank Core use cutting-edge approaches that integrate molecular and cellular neuropathology to investigate Alzheimer's disease, Parkinson's disease, Dementia with Lewy bodies, Essential Tremor, and Huntington's disease. Dr. Lin is specifically interested in the molecular signatures of selective neuronal vulnerability and blood biomarkers to delve into the origins of neurodegenerative and neuropsychiatric illnesses. 

Being responsible for the overall management and strategic planning of the Iowa NeuroBank Core, from its daily procedures to its mission and vision, Dr. Lin has technical, business, and scientific expertise in human biobanking and emerging spatial biology tools to serve as a service provider, NIH-funded investigator, and advisor.

After receiving her Master of Science (MS) degree in Physiology, Dr. Lin did her PhD work with Etienne Sibille in the Translational Neuroscience Program (TNP) and Center for Neuroscience, University of Pittsburgh (CNUP), where she focused on the selective neuronal vulnerability of interneurons in human Major Depressive Disorder (University of Pittsburgh's NIH NeuroBioBank Brain and Tissue Repository) and its mouse models. As a Tau Consortium Postdoctoral Fellow, Dr. Lin further honed her human brain expertise alongside Dr. Bill Seeley at UCSF, investigating the neuropathology of von Economo neurons in patients with Frontotemporal dementia (FTD), Progressive supranuclear palsy (PSP), and Alzheimer’s Disease (AD), supported by the Rainwater Charitable Foundation and UCSF Neurodegenerative Disease Brain Bank. Dr. Lin continues to study human postmortem brains and neurosurgical brain tissue from patients with Parkinson's Disease (PD) and Huntington's Disease (HD) while expanding and testing novel cutting-edge approaches.

To foster research collaboration, education, and community engagement,  Dr. Lin is committed to supporting education and outreach. She works as a mentor and instructor for Pre-medical undergrad and post-baccalaureate researchers collaborating within the NeuroBank Core, including individualized mentoring undergrad students from diverse backgrounds with fellowship support. These included the Office of Undergraduate Research's (OUR) Fellowships, Science Alliance (ISA) internships, and UI Louis Stokes Alliance for Minority Participation (UI-LSAMP) fellowships. Her dedication is celebrated through student success, including the 2021 Cutting-Edge Award from the John Pappajohn Entrepreneurial Center, shared with one of her students. Furthermore, she received the 2022 Distinguished mentor award from the Iowa Center for Research by Undergraduates, a recognition underscored by the Office of the Vice President for Research at the annual Discovery and Innovation Awards reception. Dr. Lin has engaged in various K-12 outreach programs, impacting over four thousand students and donors from Iowa and SF to spark curiosity and interest in health sciences.

Research Interests: human brain tissue research, tauopathies, selective vulnerability, ER stress, protein translation

Selected publications:

Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. Cell. 2024. https://doi.org/10.1016/j.cell.2024.08.019

Voss MW, Oehler C, Daniels W, Sodoma M, Madero B, Kent J, Jain S, Jung M, Nuckols VR, DuBose LE, Davis KG, O'Deen A, Hamilton C, Baller K, Springer J, Rivera-Dompenciel A, Pipoly M, Muellerleile M, Nagarajan N, Bjarnason T, Harb N, Lin LC, Magnotta V, Hazeltine E, Long JD, Pierce GL. Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial. Contemp Clin Trials. 2024. PMID: 39095013. https://pubmed.ncbi.nlm.nih.gov/39095013/

Chatterjee S, Park BJ, Vanrobaeys Y, Heiney SA, Rhone AE, Nourski KV, Langmack L, Mukherjee U, Kovach CK, Kocsis Z, Kikuchi Y, Petkov CI, Hefti MM, Bahl E, Michaelson JJ, Kawasaki H, Oya H, Howard MA 3rd, Nickl-Jockschat T, Lin LC, Abel T. Activity-induced gene expression in the human brain. bioRxiv [Preprint]. 2023. PMID: 37790527; PMCID: PMC10542502. https://pubmed.ncbi.nlm.nih.gov/37790527/

Lin LC, Cole RC, Greenlee JDW, Narayanan NS. A Pilot Study of Ex Vivo Human Prefrontal RNA Transcriptomics in Parkinson's Disease. Cellular and Molecular Neurobiology. 2023. PMID: 36952070.

Lin LC, Hollis B, Hefti MM. Neuropathology of COVID-19. Indian Journal of Pathology & Microbiology. 2022. PMID: 35562145.

Lin LC, Nana AL, Hepker M, Hwang JL, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH, Coppola G, Rosen HJ, Miller BL, Seeley WW. Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. Acta Neuropathologica Communications. 2019. PMID: 31640778.

Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Reports. 2020. PMID: 33207193.

Lin LC, Sibille E. Somatostatin, neuronal vulnerability and behavioral emotionality. Molecular Psychiatry. 2015. PMID: 25600109.

Lin LC, Lewis DA, Sibille E. A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism. Molecular Brain. 2011. PMID: 21542937.